› 2kum

Solution NMR

Solution structure of the human chemokine CCL27

Released:
DOI: 10.2210/pdb2kum/pdb
PDB entry 2kum coloured by chain, ensemble of 30 models, front view.
PDB entry 2kum coloured by chain, ensemble of 30 models, side view.
PDB entry 2kum coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27.
Jansma AL, Kirkpatrick JP, Hsu AR, Handel TM, Nietlispach D
J Biol Chem 285 14424-37 (2010)
PMID: 20200157

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 27 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y4X3 (Residues: 25-112; Coverage: 100%)
Gene names: CCL27, ILC, SCYA27
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
8 more

8 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
7 more