› 2kwx

Solution NMR

The V27A mutant of influenza A M2 proton channel

Released:
DOI: 10.2210/pdb2kwx/pdb
PDB entry 2kwx coloured by chain, ensemble of 15 models, front view.
PDB entry 2kwx coloured by chain, ensemble of 15 models, side view.
PDB entry 2kwx coloured by chain, ensemble of 15 models, top view.
Source organism: Influenza A virus (A/Udorn/307/1972(H3N2))
Primary publication:
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel.
Pielak RM, Chou JJ
Biochem Biophys Res Commun 401 58-63 (2010)
PMID: 20833142

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 38 amino acids
Theoretical weight: 4.42 KDa
Source organism: Influenza A virus (A/Udorn/307/1972(H3N2))
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DOF5 (Residues: 23-60; Coverage: 39%)
Gene name: M
Sequence domains: Influenza Matrix protein (M2)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.
Wang et al. (2011)
6 more

15 mentions without citation

Influences of membrane mimetic environments on membrane protein structures.
Zhou et al. (2013)
14 more