› 2kxa

Solution NMR

The hemagglutinin fusion peptide (H1 subtype) at pH 7.4

Released:
DOI: 10.2210/pdb2kxa/pdb
PDB entry 2kxa coloured by chain, ensemble of 10 models, front view.
PDB entry 2kxa coloured by chain, ensemble of 10 models, side view.
PDB entry 2kxa coloured by chain, ensemble of 10 models, top view.
Source organism: Influenza A virus (A/swine/Scotland/410440/94(H1N2))
Primary publication:
The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface.
Lorieau JL, Louis JM, Bax A
Proc Natl Acad Sci U S A 107 11341-6 (2010)
PMID: 20534508

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195519 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin HA2 chain Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.15 KDa
Source organism: Influenza A virus (A/swine/Scotland/410440/94(H1N2))
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9YTC2 (Residues: 345-367; Coverage: 4%)
Gene name: HA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Viral membrane fusion.
Harrison SC. (2015)
14 more

25 mentions without citation

Membrane protein structure and dynamics from NMR spectroscopy.
Hong et al. (2012)
24 more