› 2kxn

Solution NMR

NMR structure of human Tra2beta1 RRM in complex with AAGAAC RNA

Released:
DOI: 10.2210/pdb2kxn/pdb
PDB entry 2kxn coloured by chain, ensemble of 12 models, front view.
PDB entry 2kxn coloured by chain, ensemble of 12 models, side view.
PDB entry 2kxn coloured by chain, ensemble of 12 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of purine-rich RNA recognition by the human SR-like protein Tra2-β1.
Cléry A, Jayne S, Benderska N, Dominguez C, Stamm S, Allain FH
Nat Struct Mol Biol 18 443-50 (2011)
PMID: 21399644

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158892 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Transformer-2 protein homolog beta Chain: B
Molecule details ›
Chain: B
Length: 129 amino acids
Theoretical weight: 14.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P62995 (Residues: 106-200; Coverage: 33%)
Gene names: SFRS10, TRA2B
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
5'-R(*AP*AP*GP*AP*AP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.92 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

12 review citations

RRM-RNA recognition: NMR or crystallography…and new findings.
Daubner et al. (2013)
11 more

5 mentions without citation

Structural basis of nucleic acid binding by Nicotiana tabacum glycine-rich RNA-binding protein: implications for its RNA chaperone function.
Khan et al. (2014)
4 more