› 2kye

Solution NMR

Solution structure of the pseudouridine modified P6.1 hairpin of human telomerase RNA

Released:
DOI: 10.2210/pdb2kye/pdb
PDB entry 2kye coloured by chain, ensemble of 20 models, front view.
PDB entry 2kye coloured by chain, ensemble of 20 models, side view.
PDB entry 2kye coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Effect of pseudouridylation on the structure and activity of the catalytically essential P6.1 hairpin in human telomerase RNA.
Kim NK, Theimer CA, Mitchell JR, Collins K, Feigon J
Nucleic Acids Res 38 6746-56 (2010)
PMID: 20554853

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196444 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*GP*AP*GP*AP*GP*(PSU)P*(PSU)P*GP*GP*GP*CP*(PSU)P*CP*(PSU)P*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 15 nucleotides
Theoretical weight: 4.82 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PSU 4 x PSU

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

24 review citations

Regulation of human telomerase in homeostasis and disease.
Roake et al. (2020)
23 more

4 mentions without citation

Architecture of human telomerase RNA.
Zhang et al. (2011)
3 more