› 2l0x

Solution NMR

Solution structure of the 21 kDa GTPase RHEB bound to GDP

Released:
DOI: 10.2210/pdb2l0x/pdb
PDB entry 2l0x coloured by chain, ensemble of 20 models, front view.
PDB entry 2l0x coloured by chain, ensemble of 20 models, side view.
PDB entry 2l0x coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, Heumann R, Stoll R
J Biol Chem 285 33979-91 (2010)
PMID: 20685651

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP-binding protein Rheb Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 18.93 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q62639 (Residues: 6-174; Coverage: 92%)
Gene name: Rheb
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

10 review citations

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?
Singh et al. (2015)
9 more

2 mentions without citation

Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
Karassek et al. (2010)
1 more