› 2l0y

Solution NMR

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171904 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitochondrial intermembrane space import and assembly protein 40 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N4Q1 (Residues: 1-142; Coverage: 100%)
Gene names: CHCHD4, MIA40
Sequence domains: CHCH domain
Structure domains: Helix Hairpins
Cytochrome c oxidase copper chaperone Chain: B
Molecule details ›
Chain: B
Length: 67 amino acids
Theoretical weight: 7.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14061 (Residues: 1-63; Coverage: 100%)
Gene name: COX17
Sequence domains: Cytochrome C oxidase copper chaperone (COX17)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 68%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

Mitochondrial Machineries for Protein Import and Assembly.
Wiedemann et al. (2017)
31 more

4 mentions without citation

The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways.
Edwards et al. (2021)
3 more