› 2l10

Solution NMR

Solution Structure of the R6 Domain of Talin

Released:
DOI: 10.2210/pdb2l10/pdb
PDB entry 2l10 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l10 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l10 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GCK, Ballestrem C, Critchley DR, Barsukov IL
J Biol Chem 288 8238-8249 (2013)
PMID: 23389036

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 16.49 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26039 (Residues: 1206-1357; Coverage: 6%)
Gene names: Tln, Tln1
Structure domains: Talin, central domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing, molecular dynamics, torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
32 more

11 mentions without citation

Subcellular Localization and Dynamics of the Bcl-2 Family of Proteins.
Popgeorgiev et al. (2018)
10 more