› 2l1g

Solution NMR

RDC refined solution structure of the THAP zinc finger of THAP1 in complex with its 16bp RRM1 DNA target

Released:
DOI: 10.2210/pdb2l1g/pdb
PDB entry 2l1g coloured by chain, ensemble of 17 models, front view.
PDB entry 2l1g coloured by chain, ensemble of 17 models, side view.
PDB entry 2l1g coloured by chain, ensemble of 17 models, top view.
Source organism: Homo sapiens
Entry authors: Campagne S, Gervais V, Saurel O, Milon A

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115516 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
THAP domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NVV9 (Residues: 1-82; Coverage: 39%)
Gene name: THAP1
Sequence domains: THAP domain
DNA (5'-D(*GP*CP*TP*TP*GP*TP*GP*TP*GP*GP*GP*CP*AP*GP*CP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 16 nucleotides
Theoretical weight: 4.99 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(P*CP*GP*CP*TP*GP*CP*CP*CP*AP*CP*AP*CP*AP*AP*GP*C)-3') Chain: C
Molecule details ›
Chain: C
Length: 16 nucleotides
Theoretical weight: 4.81 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Rigid body docking, Semi flexible simulated annealing, Water refinement
Expression systems:
  • Escherichia coli
  • Not provided

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