› 2l1j

Solution NMR

1H assignments for ASIP(93-126, P103A, P105A, P111A, Q115Y, S124Y)

Released:
DOI: 10.2210/pdb2l1j/pdb
PDB entry 2l1j coloured by chain, ensemble of 20 models, front view.
PDB entry 2l1j coloured by chain, ensemble of 20 models, side view.
PDB entry 2l1j coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism.
Patel MP, Cribb Fabersunne CS, Yang YK, Kaelin CB, Barsh GS, Millhauser GL
J Mol Biol 404 45-55 (2010)
PMID: 20831872

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Agouti-signaling protein Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42127 (Residues: 93-126; Coverage: 31%)
Gene names: AGTI, AGTIL, ASIP, ASP
Sequence domains: Agouti protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

5 review citations

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.
García-Borrón et al. (2014)
4 more

3 mentions without citation

Loop-swapped chimeras of the agouti-related protein and the agouti signaling protein identify contacts required for melanocortin 1 receptor selectivity and antagonism.
Patel et al. (2010)
2 more