› 2l2y

Solution NMR

Thiostrepton, epimer form of residue 9

Released:
DOI: 10.2210/pdb2l2y/pdb
PDB entry 2l2y coloured by chain, ensemble of 20 models, front view.
PDB entry 2l2y coloured by chain, ensemble of 20 models, side view.
PDB entry 2l2y coloured by chain, ensemble of 20 models, top view.
Source organism: Streptomyces azureus
Primary publication:
NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Jonker HR, Baumann S, Wolf A, Schoof S, Hiller F, Schulte KW, Kirschner KN, Schwalbe H, Arndt HD
Angew Chem Int Ed Engl 50 3308-12 (2011)
PMID: 21365717

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiostrepton Chain: A
Molecule details ›
Chain: A
Length: 18 amino acids
Theoretical weight: 1.74 KDa
Source organism: Streptomyces azureus
UniProt:
  • Canonical: P0C8P8 (Residues: 56-71; Coverage: 22%)
Gene name: tpdA

Ligands and Environments

No bound ligands
5 modified residues:
Ligand DHA 2 x DHA
Ligand BB9 4 x BB9
Ligand DBU 1 x DBU
Ligand TS9 1 x TS9
Ligand MH6 1 x MH6

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics

Quick links

Citations

4 review citations

Thiopeptide antibiotics: retrospective and recent advances.
Just-Baringo et al. (2014)
3 more