› 2l3d

Solution NMR

The solution structure of the short form SWIRM domain of LSD1

Released:
DOI: 10.2210/pdb2l3d/pdb
PDB entry 2l3d coloured by chain, ensemble of 20 models, front view.
PDB entry 2l3d coloured by chain, ensemble of 20 models, side view.
PDB entry 2l3d coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Liu C, Lo K, Zhu G, Sze K

Function and Biology Details

Reaction catalysed: 
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + acceptor + H(2)O = a [histone H3]-N(6)-methyl-L-lysine(4) + formaldehyde + reduced acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129945 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific histone demethylase 1A Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60341 (Residues: 174-273; Coverage: 12%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Sequence domains: SWIRM domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

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