› 2l6a

Solution NMR

Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12

Released:
DOI: 10.2210/pdb2l6a/pdb
PDB entry 2l6a coloured by chain, ensemble of 20 models, front view.
PDB entry 2l6a coloured by chain, ensemble of 20 models, side view.
PDB entry 2l6a coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The NLRP12 pyrin domain: structure, dynamics, and functional insights.
Pinheiro AS, Eibl C, Ekman-Vural Z, Schwarzenbacher R, Peti W
J Mol Biol 413 790-803 (2011)
PMID: 21978668

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157746 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 12 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P59046 (Residues: 1-98; Coverage: 9%)
Gene names: NALP12, NLRP12, PYPAF7, RNO
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

Assembly and regulation of ASC specks.
Hoss et al. (2017)
16 more

12 mentions without citation

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes.
Sharma et al. (2021)
11 more