› 2l6k

Solution NMR

Solution Structure of a Nonphosphorylated Peptide Recognizing Domain

Released:
DOI: 10.2210/pdb2l6k/pdb
PDB entry 2l6k coloured by chain, ensemble of 20 models, front view.
PDB entry 2l6k coloured by chain, ensemble of 20 models, side view.
PDB entry 2l6k coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1.
Dai K, Liao S, Zhang J, Zhang X, Tu X
PLoS One 6 e21965 (2011)
PMID: 21765928

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tensin-2 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63HR2 (Residues: 1135-1248; Coverage: 8%)
Gene names: KIAA1075, TENC1, TNS2
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction.
Liu et al. (2012)
5 more

2 mentions without citation

Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1.
Dai et al. (2011)
1 more