› 2l7v

Solution NMR

Quindoline/G-quadruplex complex

Released:
DOI: 10.2210/pdb2l7v/pdb
PDB entry 2l7v coloured by chain, ensemble of 10 models, front view.
PDB entry 2l7v coloured by chain, ensemble of 10 models, side view.
PDB entry 2l7v coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design.
Dai J, Carver M, Hurley LH, Yang D
J Am Chem Soc 133 17673-80 (2011)
PMID: 21967482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115523 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3') Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 7.01 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand QUL 2 x QUL
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

12 review citations

MYC on the path to cancer.
Dang CV. (2012)
11 more

31 mentions without citation

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches.
Carabet et al. (2018)
30 more