› 2lc8

Solution NMR

Solution structure of the MLV readthrough pseudoknot

Released:
DOI: 10.2210/pdb2lc8/pdb
PDB entry 2lc8 coloured by chain, ensemble of 10 models, front view.
PDB entry 2lc8 coloured by chain, ensemble of 10 models, side view.
PDB entry 2lc8 coloured by chain, ensemble of 10 models, top view.
Source organism: Moloney murine leukemia virus
Primary publication:
An equilibrium-dependent retroviral mRNA switch regulates translational recoding.
Houck-Loomis B, Durney MA, Salguero C, Shankar N, Nagle JM, Goff SP, D'Souza VM
Nature 480 561-4 (2011)
PMID: 22121021

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195899 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (56-MER) Chain: A
Molecule details ›
Chain: A
Length: 63 nucleotides
Theoretical weight: 20.35 KDa
Source organism: Moloney murine leukemia virus
Expression system: Not provided
Sequence domains: Gag/pol translational readthrough site

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 21%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

23 review citations

Non-canonical translation in RNA viruses.
Firth et al. (2012)
22 more

7 mentions without citation

Viral RNA structure-based strategies to manipulate translation.
Jaafar et al. (2019)
6 more