› 2ld5

Solution NMR

Solution NMR-derived complex structure of Hoxa13 DNA binding domain bound to DNA

Released:
DOI: 10.2210/pdb2ld5/pdb
PDB entry 2ld5 coloured by chain, ensemble of 10 models, front view.
PDB entry 2ld5 coloured by chain, ensemble of 10 models, side view.
PDB entry 2ld5 coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for sequence specific DNA binding and protein dimerization of HOXA13.
Zhang Y, Larsen CA, Stadler HS, Ames JB
PLoS One 6 e23069 (2011)
PMID: 21829694

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115532 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Homeobox protein Hox-A13 Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.67 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62424 (Residues: 320-386; Coverage: 17%)
Gene names: Hox-1.10, Hoxa13
Sequence domains: Homeodomain
Structure domains: Homeodomain-like
DNA (5'-D(*CP*AP*AP*AP*TP*AP*AP*AP*AP*TP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.33 KDa
Source organism: Mus musculus
Expression system: Not provided
DNA (5'-D(P*GP*AP*TP*TP*TP*TP*AP*TP*TP*TP*G)-3') Chain: C
Molecule details ›
Chain: C
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 27%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Roles for major histocompatibility complex glycosylation in immune function.
Ryan et al. (2012)
16 other articles

2 mentions without citation

Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer.
Chandrasekaran et al. (2017)
1 more