› 2ldd

Solution NMR

Solution structure of the estrogen receptor-binding stapled peptide SP6 (Ac-EKHKILXRLLXDS-NH2)

Released:
DOI: 10.2210/pdb2ldd/pdb
PDB entry 2ldd coloured by chain, ensemble of 10 models, front view.
PDB entry 2ldd coloured by chain, ensemble of 10 models, side view.
PDB entry 2ldd coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Design and structure of stapled peptides binding to estrogen receptors.
Phillips C, Roberts LR, Schade M, Bazin R, Bent A, Davies NL, Moore R, Pannifer AD, Pickford AR, Prior SH, Read CM, Scott A, Brown DG, Xu B, Irving SL
J Am Chem Soc 133 9696-9 (2011)
PMID: 21612236

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor-binding stapled peptide SP6 Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.63 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 55%
Refinement method: simulated annealing
Expression system: Not provided

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Citations

27 review citations

Coronavirus envelope protein: current knowledge.
Schoeman et al. (2019)
26 more

1 mention without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)