› 2ldy

Solution NMR

Solution structure of the RMM-CTD domains of human LINE-1 ORF1p

Released:
DOI: 10.2210/pdb2ldy/pdb
PDB entry 2ldy coloured by chain, ensemble of 21 models, front view.
PDB entry 2ldy coloured by chain, ensemble of 21 models, side view.
PDB entry 2ldy coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition.
Khazina E, Truffault V, Büttner R, Schmidt S, Coles M, Weichenrieder O
Nat Struct Mol Biol 18 1006-14 (2011)
PMID: 21822284

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
LINE-1 retrotransposable element ORF1 protein Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UN81 (Residues: 157-330; Coverage: 52%)
Gene names: L1RE1, LRE1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Roles for retrotransposon insertions in human disease.
Hancks et al. (2016)
14 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)