› 2lgp

Solution NMR

Solution structure of LA45 from LDLR

Released:
DOI: 10.2210/pdb2lgp/pdb
PDB entry 2lgp coloured by chain, ensemble of 20 models, front view.
PDB entry 2lgp coloured by chain, ensemble of 20 models, side view.
PDB entry 2lgp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure, dynamics, and binding of the LA45 module pair of the low-density lipoprotein receptor suggest an important role for LA4 in ligand release.
Guttman M, Komives EA
Biochemistry 50 11001-8 (2011)
PMID: 22091758

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134043 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.17 KDa
Source organism: Homo sapiens
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: P01130 (Residues: 144-235; Coverage: 11%)
Gene name: LDLR
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: CELL-FREE SYNTHESIS

Quick links

Citations

12 citation in other articles

LDL receptor/lipoprotein recognition: endosomal weakening of ApoB and ApoE binding to the convex face of the LR5 repeat.
Martínez-Oliván et al. (2014)
11 more

6 mentions without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)
5 more