› 2lgr

Solution NMR

Solution structure of human protein C6orf130, a putative macro domain

Released:
DOI: 10.2210/pdb2lgr/pdb
PDB entry 2lgr coloured by chain, ensemble of 20 models, front view.
PDB entry 2lgr coloured by chain, ensemble of 20 models, side view.
PDB entry 2lgr coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties.
Peterson FC, Chen D, Lytle BL, Rossi MN, Ahel I, Denu JM, Volkman BF
J Biol Chem 286 35955-35965 (2011)
PMID: 21849506

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribose glycohydrolase OARD1 Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.05 KDa
Source organism: Homo sapiens
Expression system: CELL-FREE SYNTHESIS
UniProt:
  • Canonical: Q9Y530 (Residues: 2-152; Coverage: 99%)
Gene names: C6orf130, OARD1, TARG1
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: CELL-FREE SYNTHESIS

Quick links

Citations

24 review citations

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.
Gibson et al. (2012)
23 more

1 mention without citation

Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties.
Peterson et al. (2011)