› 2lgw

Solution NMR

Solution Structure of the J Domain of HSJ1a

Released:
DOI: 10.2210/pdb2lgw/pdb
PDB entry 2lgw coloured by chain, ensemble of 15 models, front view.
PDB entry 2lgw coloured by chain, ensemble of 15 models, side view.
PDB entry 2lgw coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.
Gao XC, Zhou CJ, Zhou ZR, Wu M, Cao CY, Hu HY
J Biol Chem 287 6044-52 (2012)
PMID: 22219199

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DnaJ homolog subfamily B member 2 Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25686 (Residues: 1-91; Coverage: 28%)
Gene names: DNAJB2, HSJ1, HSPF3
Sequence domains: DnaJ domain
Structure domains: DnaJ domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 62%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

3 review citations

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
Stricher et al. (2013)
2 more

6 mentions without citation

DNAJ Proteins in neurodegeneration: essential and protective factors.
Zarouchlioti et al. (2018)
5 more