› 2lh8

Solution NMR

Syrian hamster prion protein with thiamine

Released:
DOI: 10.2210/pdb2lh8/pdb
PDB entry 2lh8 coloured by chain, front view.
PDB entry 2lh8 coloured by chain, side view.
PDB entry 2lh8 coloured by chain, top view.
Source organism: Mesocricetus auratus
Primary publication:
The prion protein binds thiamine.
Perez-Pineiro R, Bjorndahl TC, Berjanskii MV, Hau D, Li L, Huang A, Lee R, Gibbs E, Ladner C, Dong YW, Abera A, Cashman NR, Wishart DS
FEBS J. 278 4002-14 (2011)
PMID: 21848803

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137558 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.46 KDa
Source organism: Mesocricetus auratus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04273 (Residues: 125-228; Coverage: 45%)
Gene names: PRNP, PRP
Sequence domains: Prion/Doppel alpha-helical domain
Structure domains: Prion/Doppel protein, beta-ribbon domain

Ligands and Environments

1 bound ligand:
Ligand VIB 1 x VIB
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 21%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Vitamin B1 (thiamine) and dementia.
Gibson et al. (2016)
2 more