› 2li3

Solution NMR

Structural and functional analysis of a novel potassium toxin argentinean scorpion Tityus trivittatus reveals a new kappa sub-family

Released:
DOI: 10.2210/pdb2li3/pdb
PDB entry 2li3 coloured by chain, ensemble of 20 models, front view.
PDB entry 2li3 coloured by chain, ensemble of 20 models, side view.
PDB entry 2li3 coloured by chain, ensemble of 20 models, top view.
Source organism: Tityus trivittatus
Primary publication:
New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing.
Saucedo AL, Flores-Solis D, Rodríguez de la Vega RC, Ramírez-Cordero B, Hernández-López R, Cano-Sánchez P, Noriega Navarro R, García-Valdés J, Coronas-Valderrama F, de Roodt A, Brieba LG, Domingos Possani L, del Río-Portilla F
J Biol Chem 287 12321-30 (2012)
PMID: 22238341

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-buthitoxin-Tt2b Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.33 KDa
Source organism: Tityus trivittatus
Expression system: Escherichia coli
UniProt:
  • Canonical: B3A0L5 (Residues: 1-28; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 49%
Refinement method: TORSION ANGLE DYNAMICS, MOLECULAR DYNAMICS
Expression system: Escherichia coli

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Citations

4 review citations

Scorpion venom components that affect ion-channels function.
Quintero-Hernández et al. (2013)
3 more

1 mention without citation

New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing.
Saucedo et al. (2012)