› 2liw

Solution NMR

NMR structure of HMG-ACPI domain from CurA module from Lyngbya majuscula

Released:
DOI: 10.2210/pdb2liw/pdb
PDB entry 2liw coloured by chain, ensemble of 20 models, front view.
PDB entry 2liw coloured by chain, ensemble of 20 models, side view.
PDB entry 2liw coloured by chain, ensemble of 20 models, top view.
Source organism: Lyngbya majuscula
Primary publication:
Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase.
Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V
ACS Chem Biol 7 378-86 (2012)
PMID: 22103656

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179535 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CurA Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 11.01 KDa
Source organism: Lyngbya majuscula
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6DNF2 (Residues: 1946-2034; Coverage: 4%)
Gene name: curA
Sequence domains: Phosphopantetheine attachment site
Structure domains: ACP-like

Ligands and Environments

2 bound ligands:
Ligand PNS 1 x PNS
Ligand MAH 1 x MAH
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

The structures of type I polyketide synthases.
Keatinge-Clay AT. (2012)
7 more

5 mentions without citation

Stereocontrol within polyketide assembly lines.
Keatinge-Clay AT. (2016)
4 more