› 2ljb

Solution NMR

Structure of the influenza AM2-BM2 chimeric channel

Released:
DOI: 10.2210/pdb2ljb/pdb
PDB entry 2ljb coloured by chain, ensemble of 15 models, front view.
PDB entry 2ljb coloured by chain, ensemble of 15 models, side view.
PDB entry 2ljb coloured by chain, ensemble of 15 models, top view.
Source organisms:
Primary publication:
Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.
Pielak RM, Oxenoid K, Chou JJ
Structure 19 1655-63 (2011)
PMID: 22078564

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 35 amino acids
Theoretical weight: 3.81 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9YP62 (Residues: 18-37; Coverage: 21%)
  • Canonical: B4UQM4 (Residues: 20-34; Coverage: 14%)
Gene names: BM2, M

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 5%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.
Wanka et al. (2013)
12 more

4 mentions without citation

Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily et al. (2020)
3 more