› 2lk2

Solution NMR

Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B

Released:
DOI: 10.2210/pdb2lk2/pdb
PDB entry 2lk2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lk2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lk2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Yang Y, Ramelot TA, Cort JR, Shastry R, Ciccosanti C, Hamilton K, Acton TB, Xiao R, Everett JK, Montelione GT, Kennedy MA, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172331 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox protein TGIF1 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15583 (Residues: 171-248; Coverage: 20%)
Gene names: TGIF, TGIF1
Sequence domains: Homeobox KN domain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli

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