› 2lkz

Solution NMR

Solution structure of the second RRM domain of RBM5

Released:
DOI: 10.2210/pdb2lkz/pdb
PDB entry 2lkz coloured by chain, ensemble of 20 models, front view.
PDB entry 2lkz coloured by chain, ensemble of 20 models, side view.
PDB entry 2lkz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets.
Song Z, Wu P, Ji P, Zhang J, Gong Q, Wu J, Shi Y
Biochemistry 51 6667-78 (2012)
PMID: 22839758

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein 5 Chain: A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 10.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52756 (Residues: 231-316; Coverage: 11%)
Gene names: H37, LUCA15, RBM5
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

12 citation in other articles

RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara et al. (2013)
11 more

4 mentions without citation

RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.
O'Bryan et al. (2013)
3 more