› 2lo9

Solution NMR

NMR solution structure of Mu-contoxin BuIIIB

Released:
DOI: 10.2210/pdb2lo9/pdb
PDB entry 2lo9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lo9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lo9 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus bullatus
Primary publication:
Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency.
Kuang Z, Zhang MM, Gupta K, Gajewiak J, Gulyas J, Balaram P, Rivier JE, Olivera BM, Yoshikami D, Bulaj G, Norton RS
ACS Chem Biol 8 1344-51 (2013)
PMID: 23557677

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111122 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin BuIIIB Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.78 KDa
Source organism: Conus bullatus
Expression system: Not provided
UniProt:
  • Canonical: C1J5M6 (Residues: 52-75; Coverage: 43%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 78%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Animal toxins influence voltage-gated sodium channel function.
Gilchrist et al. (2014)
2 more

6 mentions without citation

Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.
Green et al. (2014)
5 more