› 2loa

Solution NMR

Structural Basis for Bifunctional Zn(II) Macrocyclic Complex Recognition of Thymine Bulges in DNA

Released:
DOI: 10.2210/pdb2loa/pdb
PDB entry 2loa coloured by chain, front view.
PDB entry 2loa coloured by chain, side view.
PDB entry 2loa coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Structural basis for bifunctional zinc(II) macrocyclic complex recognition of thymine bulges in DNA.
del Mundo IM, Siters KE, Fountain MA, Morrow JR
Inorg Chem 51 5444-57 (2012)
PMID: 22507054

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115556 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*CP*CP*GP*CP*AP*GP*TP*GP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand C4Q 1 x C4Q
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 22%
Refinement method: DGSA-distance geometry simulated annealing, Docking with energy minimization
Expression system: Not provided

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Citations

1 review citation

Metal-Based G-Quadruplex Binders for Cancer Theranostics.
Palma et al. (2021)
11 other articles

1 mention without citation

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors.
Jeddi et al. (2017)