› 2lrr

Solution NMR

Solution structure of the R3H domain from human Smubp-2 in complex with 2'-deoxyguanosine-5'-monophosphate

Released:
DOI: 10.2210/pdb2lrr/pdb
PDB entry 2lrr coloured by chain, ensemble of 20 models, front view.
PDB entry 2lrr coloured by chain, ensemble of 20 models, side view.
PDB entry 2lrr coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for 5'-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2.
Jaudzems K, Jia X, Yagi H, Zhulenkovs D, Graham B, Otting G, Liepinsh E
J Mol Biol 424 42-53 (2012)
PMID: 22999958

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153775 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA-binding protein SMUBP-2 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P38935 (Residues: 711-786; Coverage: 8%)
Gene names: IGHMBP2, SMBP2, SMUBP2
Sequence domains: R3H domain
Structure domains: R3H-like domain

Ligands and Environments

1 bound ligand:
Ligand DGP 1 x DGP
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 50%
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Single-stranded DNA-binding proteins: multiple domains for multiple functions.
Dickey et al. (2013)
3 more

3 mentions without citation

ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides.
Ahmad et al. (2013)
2 more