› 2lsl

Solution NMR

Solution structure of the C-terminal domain of Tetrahymena telomerase protein p65

Released:
DOI: 10.2210/pdb2lsl/pdb
PDB entry 2lsl coloured by chain, ensemble of 20 models, front view.
PDB entry 2lsl coloured by chain, ensemble of 20 models, side view.
PDB entry 2lsl coloured by chain, ensemble of 20 models, top view.
Source organism: Tetrahymena thermophila
Primary publication:
Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.
Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J
Mol Cell 47 16-26 (2012)
PMID: 22705372

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
La-related protein 7 homolog Chain: A
Molecule details ›
Chain: A
Length: 137 amino acids
Theoretical weight: 16.19 KDa
Source organism: Tetrahymena thermophila
Expression system: Escherichia coli
UniProt:
  • Canonical: W7X6T2 (Residues: 369-519; Coverage: 24%)
Gene names: TAP65, TTHERM_000318539

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli

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Citations

26 review citations

Biogenesis of telomerase ribonucleoproteins.
Egan et al. (2012)
25 more

2 mentions without citation

Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.
Singh et al. (2012)
1 more