› 2lti

Solution NMR

Structure of lasso peptide Astexin1

Released:
DOI: 10.2210/pdb2lti/pdb
PDB entry 2lti coloured by chain, ensemble of 20 models, front view.
PDB entry 2lti coloured by chain, ensemble of 20 models, side view.
PDB entry 2lti coloured by chain, ensemble of 20 models, top view.
Source organism: Asticcacaulis excentricus CB 48
Primary publication:
Precursor-centric genome-mining approach for lasso peptide discovery.
Maksimov MO, Pelczer I, Link AJ
Proc Natl Acad Sci U S A 109 15223-8 (2012)
PMID: 22949633

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astexin-1 Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.58 KDa
Source organism: Asticcacaulis excentricus CB 48
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: E8RMD3 (Residues: 29-51; Coverage: 45%)
Gene names: Astex_2228, AtxA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: STRUCTURES WERE CALCULATED BY TORSION ANGLE DYNAMICS AND SIMULATED ANNEALING.
Expression system: Escherichia coli BL21

Quick links

Citations

21 review citations

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
Arnison et al. (2013)
20 more

2 mentions without citation

Precursor-centric genome-mining approach for lasso peptide discovery.
Maksimov et al. (2012)
1 more