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Solution NMR

Solution NMR Structure of NFU1 Iron-Sulfur Cluster Scaffold Homolog from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR2876B

Released:
DOI: 10.2210/pdb2ltm/pdb
PDB entry 2ltm coloured by chain, ensemble of 20 models, front view.
PDB entry 2ltm coloured by chain, ensemble of 20 models, side view.
PDB entry 2ltm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Liu G, Xiao R, Janjua H, Hamilton K, Shastry R, Kohan E, Acton TB, Everett JK, Lee H, Huang YJ, Montelione GT, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193971 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UMS0 (Residues: 59-155; Coverage: 38%)
Gene names: CGI-33, HIRIP5, NFU1
Sequence domains: Scaffold protein Nfu/NifU N terminal
Structure domains: Scaffold protein Nfu/NifU, N-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: distance geometry, simulated annealing, torsion angle dynamics, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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