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Solution NMR

Solution NMR structure of C2H2-type Zinc-fingers 4 and 5 from human Insulinoma-associated protein 1 (fragment 424-497), Northeast Structural Genomics Consortium Target HR7614B

Released:
DOI: 10.2210/pdb2lv2/pdb
PDB entry 2lv2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lv2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lv2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Yang Y, Ramelot TA, Cort JR, Shastry R, Kohan E, Janjua H, Xiao R, Acton T, Everett JK, Montelione GT, Kennedy MA, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulinoma-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q01101 (Residues: 424-497; Coverage: 15%)
Gene names: IA1, INSM1
Sequence domains: Zinc finger, C2H2 type
Structure domains: Classic Zinc Finger

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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