› 2lv9

Solution NMR

Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium target HR6512A

Released:
DOI: 10.2210/pdb2lv9/pdb
PDB entry 2lv9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lv9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lv9 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Lemak A, Yee A, Houliston S, Garcia M, Wu H, Min J, Montelione GT, Arrowsmith C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inactive histone-lysine N-methyltransferase 2E Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZD2 (Residues: 109-188; Coverage: 4%)
Gene names: KMT2E, MLL5
Sequence domains: PhD finger domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: restrained molecular dynamics
Expression system: Escherichia coli

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