› 2lw7

Solution NMR

NMR solution structure of human HisRS splice variant

Released:
DOI: 10.2210/pdb2lw7/pdb
PDB entry 2lw7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lw7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lw7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ye F, Wei Z, Wu J, Schimmel P, Zhang M

Function and Biology Details

Reaction catalysed: 
ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine--tRNA ligase, cytoplasmic Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12081 (Residues: 2-509; Coverage: 33%)
Gene names: HARS, HARS1, HRS
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 74%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

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