› 2lxb

Solution NMR

Solution structure of the Sgt2 homodimerization domain

Released:
DOI: 10.2210/pdb2lxb/pdb
PDB entry 2lxb coloured by chain, ensemble of 10 models, front view.
PDB entry 2lxb coloured by chain, ensemble of 10 models, side view.
PDB entry 2lxb coloured by chain, ensemble of 10 models, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.
Chartron JW, VanderVelde DG, Clemons WM
Cell Rep 2 1620-32 (2012)
PMID: 23142665

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171297 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small glutamine-rich tetratricopeptide repeat-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 74 amino acids
Theoretical weight: 7.89 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12118 (Residues: 2-72; Coverage: 21%)
Gene names: SGT2, UNF346, YOR007C
Sequence domains: Homodimerisation domain of SGTA
Structure domains: Immunoglobulin FC, subunit C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion.
Chio et al. (2017)
9 more

2 mentions without citation

Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha.
Roberts et al. (2015)
1 more