› 2lxg

Solution NMR

NMR solution structure of Mu-conotoxin KIIIA

Released:
DOI: 10.2210/pdb2lxg/pdb
PDB entry 2lxg coloured by chain, ensemble of 20 models, front view.
PDB entry 2lxg coloured by chain, ensemble of 20 models, side view.
PDB entry 2lxg coloured by chain, ensemble of 20 models, top view.
Source organism: Conus kinoshitai
Primary publication:
Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels.
Khoo KK, Gupta K, Green BR, Zhang MM, Watkins M, Olivera BM, Balaram P, Yoshikami D, Bulaj G, Norton RS
Biochemistry 51 9826-35 (2012)
PMID: 23167564

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-conotoxin KIIIA Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.89 KDa
Source organism: Conus kinoshitai
Expression system: Not provided
UniProt:
  • Canonical: P0C195 (Residues: 5-20; Coverage: 73%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 62%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

9 review citations

Sodium channels and pain: from toxins to therapies.
Cardoso et al. (2018)
8 more

18 mentions without citation

Conotoxin gene superfamilies.
Robinson et al. (2014)
17 more