› 2lxz

Solution NMR

Solution Structure of the Antimicrobial Peptide Human Defensin 5

Released:
DOI: 10.2210/pdb2lxz/pdb
PDB entry 2lxz coloured by chain, ensemble of 20 models, front view.
PDB entry 2lxz coloured by chain, ensemble of 20 models, side view.
PDB entry 2lxz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5.
Wommack AJ, Robson SA, Wanniarachchi YA, Wan A, Turner CJ, Wagner G, Nolan EM
Biochemistry 51 9624-37 (2012)
PMID: 23163963

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 72%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Defensins in innate immunity.
Zhao et al. (2014)
2 more

10 mentions without citation

Antimicrobial Peptides: Mechanisms of Action and Resistance.
Bechinger et al. (2017)
9 more