› 2m01

Solution NMR

Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom

Released:
DOI: 10.2210/pdb2m01/pdb
PDB entry 2m01 coloured by chain, ensemble of 20 models, front view.
PDB entry 2m01 coloured by chain, ensemble of 20 models, side view.
PDB entry 2m01 coloured by chain, ensemble of 20 models, top view.
Source organism: Lychas mucronatus
Primary publication:
Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins.
Chen Z, Luo F, Feng J, Yang W, Zeng D, Zhao R, Cao Z, Liu M, Li W, Jiang L, Wu Y
PLoS One 8 e60201 (2013)
PMID: 23573241

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kunitz-type serine protease inhibitor LmKTT-1a Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.51 KDa
Source organism: Lychas mucronatus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DJ46 (Residues: 22-80; Coverage: 100%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals.
Mourão et al. (2013)
3 more

3 mentions without citation

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins.
Chen et al. (2013)
2 more