› 2m1s

Solution NMR

NMR assignment of the arenaviral protein Z from Lassa fever virus

Released:
DOI: 10.2210/pdb2m1s/pdb
PDB entry 2m1s coloured by chain, ensemble of 10 models, front view.
PDB entry 2m1s coloured by chain, ensemble of 10 models, side view.
PDB entry 2m1s coloured by chain, ensemble of 10 models, top view.
Source organism: Lassa virus Josiah
Primary publication:
Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.
Volpon L, Osborne MJ, Capul AA, de la Torre JC, Borden KL
Proc Natl Acad Sci U S A 107 5441-6 (2010)
PMID: 20212144

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RING finger protein Z Chain: A
Molecule details ›
Chain: A
Length: 99 amino acids
Theoretical weight: 10.69 KDa
Source organism: Lassa virus Josiah
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O73557 (Residues: 1-99; Coverage: 100%)
Gene name: Z
Sequence domains: P-11 zinc finger
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?
Borden et al. (2010)
20 more

4 mentions without citation

Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins.
Ferron et al. (2017)
3 more