› 2m27

Solution NMR

Major G-quadruplex structure formed in human VEGF promoter, a monomeric parallel-stranded quadruplex

Released:
DOI: 10.2210/pdb2m27/pdb
PDB entry 2m27 coloured by chain, ensemble of 10 models, front view.
PDB entry 2m27 coloured by chain, ensemble of 10 models, side view.
PDB entry 2m27 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes.
Agrawal P, Hatzakis E, Guo K, Carver M, Yang D
Nucleic Acids Res 41 10584-92 (2013)
PMID: 24005038

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115581 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA_(5'-D(*CP*GP*GP*GP*GP*CP*GP*GP*GP*CP*CP*TP*TP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3')_ Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.92 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Formation and processing of DNA damage substrates for the hNEIL enzymes.
Fleming et al. (2017)
3 more

12 mentions without citation

8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis.
Fleming et al. (2017)
11 more