› 2m37

Solution NMR

Structure of lasso peptide astexin-1

Released:
DOI: 10.2210/pdb2m37/pdb
PDB entry 2m37 coloured by chain, ensemble of 20 models, front view.
PDB entry 2m37 coloured by chain, ensemble of 20 models, side view.
PDB entry 2m37 coloured by chain, ensemble of 20 models, top view.
Source organism: Asticcacaulis excentricus CB 48
Primary publication:
The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.
Zimmermann M, Hegemann JD, Xie X, Marahiel MA
Chem Biol 20 558-69 (2013)
PMID: 23601645

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astexin-1 Chain: A
Molecule details ›
Chain: A
Length: 19 amino acids
Theoretical weight: 2.11 KDa
Source organism: Asticcacaulis excentricus CB 48
Expression system: Asticcacaulis excentricus
UniProt:
  • Canonical: E8RMD3 (Residues: 29-47; Coverage: 37%)
Gene names: Astex_2228, AtxA1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 49%
Refinement method: simulated annealing
Expression system: Asticcacaulis excentricus

Quick links

Citations

8 review citations

Lasso Peptides: Heterologous Production and Potential Medical Application.
Cheng et al. (2020)
7 more

2 mentions without citation

Challenges and advances in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs).
Zhong et al. (2020)
1 more