› 2m3l

Solution NMR

Solution structure of the C-terminal zinc-binding domain of HPV51 oncoprotein E6

Released:
DOI: 10.2210/pdb2m3l/pdb
PDB entry 2m3l coloured by chain, ensemble of 20 models, front view.
PDB entry 2m3l coloured by chain, ensemble of 20 models, side view.
PDB entry 2m3l coloured by chain, ensemble of 20 models, top view.
Source organism: human papillomavirus 51
Primary publication:
Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain.
Mischo A, Ohlenschläger O, Hortschansky P, Ramachandran R, Görlach M
PLoS One 8 e62584 (2013)
PMID: 23638119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150774 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein E6 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.95 KDa
Source organism: human papillomavirus 51
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26554 (Residues: 80-151; Coverage: 48%)
Gene name: E6
Sequence domains: Early Protein (E6)
Structure domains: E6 early regulatory protein

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: DGSA-distance geometry simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Specificity in PDZ-peptide interaction networks: Computational analysis and review.
Amacher et al. (2020)
3 more

1 mention without citation

Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain.
Mischo et al. (2013)