2m3m

Solution NMR

Solution structure of a complex consisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-150775 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disks large homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12959 (Residues: 318-406; Coverage: 10%)
Gene name: DLG1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Protein E6 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.4 KDa
Source organism: human papillomavirus 51
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26554 (Residues: 141-151; Coverage: 7%)
Gene name: E6

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 96%
Refinement method: DGSA-distance geometry simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)