› 2m4p

Solution NMR

Solution structure of an intramolecular propeller-type G-quadruplex containing a single bulge

Released:
DOI: 10.2210/pdb2m4p/pdb
PDB entry 2m4p coloured by chain, ensemble of 10 models, front view.
PDB entry 2m4p coloured by chain, ensemble of 10 models, side view.
PDB entry 2m4p coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Bulges in G-quadruplexes: broadening the definition of G-quadruplex-forming sequences.
Mukundan VT, Phan AT
J Am Chem Soc 135 5017-28 (2013)
PMID: 23521617

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115589 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*TP*GP*TP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') Chain: A
Molecule details ›
Chain: A
Length: 19 nucleotides
Theoretical weight: 6.03 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: DGSA-distance geometry simulated annealing, simulated annealing, molecular dynamics
Expression system: Not provided

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Citations

27 review citations

The Structure and Function of DNA G-Quadruplexes.
Spiegel et al. (2020)
26 more

11 mentions without citation

G-quadruplexes in viruses: function and potential therapeutic applications.
Métifiot et al. (2014)
10 more