› 2m53

Solution NMR

G-rich VEGF aptamer with LNA modifications

Released:
DOI: 10.2210/pdb2m53/pdb
PDB entry 2m53 coloured by chain, ensemble of 10 models, front view.
PDB entry 2m53 coloured by chain, ensemble of 10 models, side view.
PDB entry 2m53 coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold.
Marušič M, Veedu RN, Wengel J, Plavec J
Nucleic Acids Res 41 9524-36 (2013)
PMID: 23935071

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115590 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
G-rich VEGF aptamer Chain: A
Molecule details ›
Chain: A
Length: 25 nucleotides
Theoretical weight: 8 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand LCG 3 x LCG

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 36%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

G-quadruplex-based aptamers against protein targets in therapy and diagnostics.
Platella et al. (2017)
5 more

7 mentions without citation

Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices.
Malecka et al. (2021)
6 more