› 2m5f

Solution NMR

NMR Structure of the Complete Internal Fusion Loop mutant L529A/I544A from Ebolavirus GP2 at pH 5.5

Released:
DOI: 10.2210/pdb2m5f/pdb
PDB entry 2m5f coloured by chain, ensemble of 20 models, front view.
PDB entry 2m5f coloured by chain, ensemble of 20 models, side view.
PDB entry 2m5f coloured by chain, ensemble of 20 models, top view.
Source organism: Zaire ebolavirus
Primary publication:
Ebolavirus entry requires a compact hydrophobic fist at the tip of the fusion loop.
Gregory SM, Larsson P, Nelson EA, Kasson PM, White JM, Tamm LK
J Virol 88 6636-49 (2014)
PMID: 24696482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109034 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filoviruses glycoprotein extracellular domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 5.86 KDa
Source organism: Zaire ebolavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: A9QPL9 (Residues: 507-560; Coverage: 8%)
Gene name: GP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Fusion of Enveloped Viruses in Endosomes.
White et al. (2016)
5 more

1 mention without citation

Ebolavirus entry requires a compact hydrophobic fist at the tip of the fusion loop.
Gregory et al. (2014)