› 2m7i

Solution NMR

Solution structure of a Beta-Hairpin Peptidomimetic antibiotic that targets LptD in Pseudomonas sp.

Released:
DOI: 10.2210/pdb2m7i/pdb
PDB entry 2m7i coloured by chain, ensemble of 20 models, front view.
PDB entry 2m7i coloured by chain, ensemble of 20 models, side view.
PDB entry 2m7i coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp.
Schmidt J, Patora-Komisarska K, Moehle K, Obrecht D, Robinson JA
Bioorg Med Chem 21 5806-10 (2013)
PMID: 23932450

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162976 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-Hairpin Peptidomimetic antibiotic TWL(DAB)(ORN)(DLY)RW(ORN)(DAB)AK(DPR)P Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.71 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
4 modified residues:
Ligand DAB 2 x DAB
Ligand ORN 2 x ORN
Ligand DLY 1 x DLY
Ligand DPR 1 x DPR

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 62%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

6 review citations

The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs.
Boto et al. (2018)
5 more

1 mention without citation

Green synthesised AuNps using Ajuga Bracteosa extract and AuNps-Free supernatant exhibited equivalent antibacterial and anticancerous efficacies.
Raja et al. (2023)